When undergoing IVF, the journey towards parenthood can be fraught with challenges, and one of the most disheartening obstacles is recurrent implantation failure. When embryos fail to implant into the uterine lining despite multiple attempts, it can leave patients feeling frustrated and hopeless. So, what can be done when embryos won’t “stick”?

What to do when your embryos won’t “stick”? When undergoing IVF, the journey towards parenthood can be fraught with challenges, and one of the most disheartening obstacles is recurrent implantation failure. When embryos fail to implant into the uterine lining despite multiple attempts, it can leave patients feeling frustrated and hopeless. So, what can be done when embryos won’t “stick”? When your embryos have been transferred multiple times and are not implanted into the uterine lining, this is called recurrent implantation failure. Recurrent implantation failure is a complex issue, and its definition can vary among medical professionals. In the United States, doctors often consider recurrent implantation failure as the absence of pregnancy after the transfer of three genetically tested and deemed "normal" (euploid) embryos. However, there are other factors that can impact implantation. This includes ensuring the endometrium, the uterine lining, is of appropriate thickness and quality. Monitoring and optimising hormonal balance in the ovaries is also crucial for creating a receptive environment for embryo implantation. Also, the handling of embryos in the laboratory plays a significant role. Optimal warming conditions during embryo transfer, especially when embryos are taken out of storage, can influence their viability and likelihood of successful implantation. One reason the doctors in the USA set the requirement of genetic normality is because a major cause of implantation failure is genetic abnormality of the embryo despite the embryo having a normal and healthy appearance in the laboratory. Despite adhering to these best practices, if recurrent implantation failure persists after transferring three genetically normal and high-quality embryos, it's time to reassess the management plan. While there isn't a lot of guiding evidence, exploring alternative avenues becomes imperative. These include: Hysteroscopy This procedure involves examining the inside of the uterus for any signs of endometritis (inflammation of the lining of the uterus). Window of Implantation Testing By evaluating the receptivity of the uterus during the optimal implantation window. Monitoring Blood Sugar Levels High blood sugar levels can adversely affect the uterine environment, making it less conducive to implantation. Checking for and managing elevated blood sugar levels can be crucial in optimising conditions for conception. Other Ways to Optimise the Uterine Environment This might involve exploring various supplements, lifestyle modifications, or alternative therapies aimed at enhancing the uterine environment and improving the chances of successful implantation. Recurrent implantation failure can be a frustrating and disheartening experience if you’re undergoing IVF. However, by addressing potential underlying issues, conducting well-conducted cycles, and exploring alternative strategies, you can increase your chances of achieving a successful pregnancy.